![]() However, the long-term use of CVCs carries a risk of catheter-related bloodstream infections (CRBSI) that are associated with increased morbidity and mortality rates. However, the quality of current evidence is not high and further high-quality large scale RCTs are needed to corroborate our results.Ĭentral venous catheters (CVCs) are often an inevitable part of treating adult and pediatric patients receiving antibiotic therapy, parenteral nutrition, hemodialysis, chemotherapy, or hospitalized in Intensive Care Units. The use of taurolidine as a catheter locking solution may significantly reduce CRBSI in pediatric patients. The quality of the included studies was not high. The number of catheters removed due to infection or suspected infection was not significantly different between the two groups (RR: 0.68 95% CI:0.22, 2.10 I 2 = 56% P = 0.50) ( Fig 5). The pooled analysis also indicated a statistical significant reduction in the incidence of CRBSI (defined as the number of CRBSI events/1000 catheter days) in the taurolidine group (MD: -1.12 95% CI:-1.54, -0.71 I 2 = 1% P<0.00001). Our results indicated a statistical significant reduction in the total number of CRBSI with taurolidine as compared to control (RR: 0.23 95% CI:0.13, 0.40 I 2 = 0% P<0.00001). ![]() Eligible studies included randomized controlled trials (RCTs) comparing the effects of taurolidine with control for preventing CRBSI in pediatric patients. We conducted an electronic search of the PubMed, EMBASE, Cochrane Library, TRIP Database, CINAHL, and Google Scholar databases for articles published up to 1 st November 2019. The purpose of this study was to systematically search the literature and conduct a meta-analysis to determine the efficacy of taurolidine in reducing CRBSI in children. Taurolidine lock solutions have been used to decrease catheter-related bloodstream infections (CRBSIs) in both adult and pediatric patients. Infection is one of the most commonly described complications, and a major cause of morbidity and mortality in pediatric patients treated using central venous catheters (CVCs).
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